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Article

Polymorphisms in TS, MTHFR and ERCC1 genes as predictive markers in first-line platinum and pemetrexed therapy in NSCLC patients.

Journal of cancer research and clinical oncology - 1 Dec 2014

Krawczyk Paweł, Kucharczyk Tomasz, Kowalski Dariusz M, Powrózek Tomasz, Ramlau Rodryg, Kalinka-Warzocha Ewa, Winiarczyk Kinga, Knetki-Wróblewska Magdalena, Wojas-Krawczyk Kamila, Kałakucka Katarzyna, Dyszkiewicz Wojciech, Krzakowski Maciej, Milanowski Janusz

Abstract excerpt

PURPOSE: We presented retrospective analysis of up to five polymorphisms in TS, MTHFR and ERCC1 genes as molecular predictive markers for homogeneous Caucasian, non-squamous NSCLC patients treated with pemetrexed and platinum front-line chemotherapy. METHODS: The following polymorphisms in DNA isolated from 115 patients were analyzed: various number of 28-bp tandem repeats in 5'-UTR region of TS gene, single...

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Source

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Identifiers

PMID: 25028118
DOI: 10.1007/s00432-014-1756-6
PMCID: PMC4228108

Genes

MTHFR
ERCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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