Article
Predictive value of ERCC1 and RRM1 gene single-nucleotide polymorphisms for first-line platinum- and gemcitabine-based chemotherapy in non-small cell lung cancer patients.
Oncology reports - 1 Nov 2013
Mlak Radosław, Krawczyk Paweł, Ramlau Rodryg, Kalinka-Warzocha Ewa, Wasylecka-Morawiec Maja, Wojas-Krawczyk Kamila, Kucharczyk Tomasz, Homa Iwona, Kozioł Piotr, Ciesielka Marzanna, Chudziak Dorota, Milanowski Janusz
Abstract excerpt
Platinum-based chemotherapy with third generation drugs (such as gemcitabine) is an efficacious regimen of first-line treatment of patients with advanced, unresectable non-small cell lung cancer (NSCLC), without activating EGFR mutations. Mechanism of action of cytostatics are distortions in the DNA. ERCC1 and RRM1 are key proteins involved in the repair of DNA, thus, they may be responsible for the...
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