Article
The histomorphology of Lynch syndrome-associated ovarian carcinomas: toward a subtype-specific screening strategy.
The American journal of surgical pathology - 1 Sept 2014
Chui Michael Herman, Ryan Paul, Radigan Jordan, Ferguson Sarah E, Pollett Aaron, Aronson Melyssa, Semotiuk Kara, Holter Spring, Sy Keiyan, Kwon Janice S, Soma Anita, Singh Naveena, Gallinger Steven, Shaw Patricia, Arseneau Jocelyne, Foulkes William D, Gilks C Blake, Clarke Blaise A
Abstract excerpt
Women with Lynch syndrome (LS) are at increased risk for the development of epithelial ovarian cancer (OC). Analogous to previous studies on BRCA1/2 mutation carriers, there is evidence to suggest a histotype-specific association in LS-associated OCs (LS-OC). Whereas the diagnosis of high-grade serous carcinoma is an indication for BRCA1/2 germline testing, in contrast, there are no screening guidelines in place...
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