Article
Combined linkage and association studies show that HLA class II variants control levels of antibodies against Epstein-Barr virus antigens.
PloS one - 1 Jan 2014
Pedergnana Vincent, Syx Laurène, Cobat Aurélie, Guergnon Julien, Brice Pauline, Fermé Christophe, Carde Patrice, Hermine Olivier, Le-Pendeven Catherine, Amiel Corinne, Taoufik Yassine, Alcaïs Alexandre, Theodorou Ioannis, Besson Caroline, Abel Laurent
Abstract excerpt
Over 95% of the adult population worldwide is infected with Epstein-Barr virus (EBV). EBV infection is associated with the development of several cancers, including Hodgkin lymphoma (HL). Elevated levels of anti-EBV antibodies have been associated with increased risk of HL. There is growing evidence that genetic factors control the levels of antibodies against EBV antigens. Here, we conducted linkage and...
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