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Article

Unique mutation portraits and frequent COL2A1 gene alteration in chondrosarcoma.

Genome research - 1 Sept 2014

Totoki Yasushi, Yoshida Akihiko, Hosoda Fumie, Nakamura Hiromi, Hama Natsuko, Ogura Koichi, Yoshida Aki, Fujiwara Tomohiro, Arai Yasuhito, Toguchida Junya, Tsuda Hitoshi, Miyano Satoru, Kawai Akira, Shibata Tatsuhiro

Abstract excerpt

Chondrosarcoma is the second most frequent malignant bone tumor. However, the etiological background of chondrosarcomagenesis remains largely unknown, along with details on molecular alterations and potential therapeutic targets. Massively parallel paired-end sequencing of whole genomes of 10 primary chondrosarcomas revealed that the process of accumulation of somatic mutations is homogeneous irrespective of the...

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Identifiers

PMID: 25024164
DOI: 10.1101/gr.160598.113
PMCID: PMC4158757

Genes

IDH1
YEATS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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