[Mantle cell lymphoma: Towards a personalized therapeutic strategy?].

doi:10.1016/j.medcli.2014.04.025

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Article

[Mantle cell lymphoma: Towards a personalized therapeutic strategy?].

Medicina clinica - 22 Jun 2015

Navarro Matilla Belén, García-Marco José A

Abstract excerpt

Mantle cell lymphoma (MCL) is a clinically heterogeneous non-Hodgkin lymphoma with an aggressive clinical behaviour and short survival in some cases and an indolent course in others. Advances in the biology and pathogenesis of MCL have unveiled several genes involved in deregulation of cell cycle checkpoints and the finding of subclonal populations with specific recurrent mutations (p53, ATM, NOTCH2) with an...

Topics

Age Factors
Antineoplastic Combined Chemotherapy Protocols
Combined Modality Therapy
Diagnosis, Differential
Disease Progression
Genes, cdc
Hematopoietic Stem Cell Transplantation
Humans
Immunologic Factors
Immunophenotyping
Immunotherapy
Lymphoma, Mantle-Cell
Lymphoproliferative Disorders
Molecular Targeted Therapy
Mutation
Neoplasm Proteins
Palliative Care
Precision Medicine

Source

Open in PubMed

Identifiers

PMID: 25023849
DOI: 10.1016/j.medcli.2014.04.025

Genes

ATM
NOTCH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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