Article
Targeted injection of a biocomposite material alters macrophage and fibroblast phenotype and function following myocardial infarction: relation to left ventricular remodeling.
The Journal of pharmacology and experimental therapeutics - 1 Sept 2014
McGarvey Jeremy R, Pettaway Sara, Shuman James A, Novack Craig P, Zellars Kia N, Freels Parker D, Echols Randall L, Burdick Jason A, Gorman Joseph H, Gorman Robert C, Spinale Francis G
Abstract excerpt
A treatment target for progressive left ventricular (LV) remodeling prevention following myocardial infarction (MI) is to affect structural changes directly within the MI region. One approach is through targeted injection of biocomposite materials, such as calcium hydroxyapatite microspheres (CHAM), into the MI region. In this study, the effects of CHAM injections upon key cell types responsible for the MI...
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