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Article

Increased sensitivity to ionizing radiation by targeting the homologous recombination pathway in glioma initiating cells

27 Jun 2014

Abstract excerpt

Glioblastoma is deemed the most malignant form of brain tumour, particularly due to its resistance to conventional treatments. A small surviving group of aberrant stem cells termed glioma initiation cells (GICs) that escape surgical debulking are suggested to be the cause of this resistance. Relatively quiescent in nature, GICs are capable of driving tumour recurrence and undergo lineage differentiation. Most...

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PMID: 25017126
DOI: 10.1016/j.molonc.2014.06.012

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