Article
PARP targeting counteracts gliomagenesis through induction of mitotic catastrophe and aggravation of deficiency in homologous recombination in PTEN-mutant glioma.
Oncotarget - 10 Mar 2015
Majuelos-Melguizo Jara, Rodríguez María Isabel, López-Jiménez Laura, Rodríguez-Vargas Jose M, Martí Martín-Consuegra Juan M, Serrano-Sáenz Santiago, Gavard Julie, de Almodóvar J Mariano Ruiz, Oliver F Javier
Abstract excerpt
Glioblastoma multiforme (GBM) is the most common primary brain tumour in adults and one of the most aggressive cancers. PARP-1 is a nuclear protein involved in multiple facets of DNA repair and transcriptional regulation. In this study we dissected the action of PARP inhibition in different GBM cell lines with either functional or mutated PTEN that confers resistance to diverse therapies. In PTEN mutant cells,...
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