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Article

Abrogation of radioresistance in glioblastoma stem‐like cells by inhibition of ATM kinase

24 Aug 2014

Abstract excerpt

Resistance to radiotherapy in glioblastoma (GBM) is an important clinical problem and several authors have attributed this to a subpopulation of GBM cancer stem cells (CSCs) which may be responsible for tumour recurrence following treatment. It is hypothesised that GBM CSCs exhibit upregulated DNA damage responses and are resistant to radiation but the current literature is conflicting. We investigated...

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PMID: 25205037
DOI: 10.1016/j.molonc.2014.08.003

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