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Article

A radiosensitizing effect of RAD51 inhibition in glioblastoma stem-like cells

5 Aug 2016

Abstract excerpt

BACKGROUND: Radioresistant glioblastoma stem cells (GSCs) contribute to tumor recurrence and identification of the molecular targets involved in radioresistance mechanisms is likely to enhance therapeutic efficacy. This study analyzed the DNA damage response following ionizing radiation (IR) in 10 GSC lines derived from patients. METHODS: DNA damage was quantified by Comet assay and DNA repair effectors were...

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PMID: 27495836
DOI: 10.1186/s12885-016-2647-9

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