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Article

Correlation between in vitro cytotoxicity and in vivo lethal activity in mice of epsilon toxin mutants from Clostridium perfringens.

PloS one - 1 Jan 2014

Dorca-Arévalo Jonatan, Pauillac Serge, Díaz-Hidalgo Laura, Martín-Satué Mireia, Popoff Michel R, Blasi Juan

Abstract excerpt

Epsilon toxin (Etx) from Clostridium perfringens is a pore-forming protein with a lethal effect on livestock, producing severe enterotoxemia characterized by general edema and neurological alterations. Site-specific mutations of the toxin are valuable tools to study the cellular and molecular mechanism of the toxin activity. In particular, mutants with paired cysteine substitutions that affect the membrane...

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Source

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Identifiers

PMID: 25013927
DOI: 10.1371/journal.pone.0102417
PMCID: PMC4094505

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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