Article

Attenuated Clostridium perfringens Epsilon Toxin Mutants and Insights into the Mechanism of Attenuation

2025-07-04

Abstract excerpt

Clostridium perfringens epsilon toxin (ETX) is a potent pore-forming exotoxin responsible for severe enterotoxemia and necrotizing enterocolitis in ruminants. To elucidate the molecular mechanisms underlying ETX pathogenicity and attenuation, several site-directed mutants—ETX-R25A, ETX-F92A, ETX-Y133A, ETX-F206A, ETX-D210A, and ETX-G221A—were constructed based on structural analysis. Cytotoxicity assays revealed r...

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Literature Corpus work: 1971526f-efd9-5596-8729-144e141db73a
DOI: 10.22541/au.175161972.24940605/v1

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