Article
Epsilon-toxin is required for most Clostridium perfringens type D vegetative culture supernatants to cause lethality in the mouse intravenous injection model.
Infection and immunity - 1 Nov 2005
Sayeed Sameera, Fernandez-Miyakawa M E, Fisher Derek J, Adams Vicki, Poon Rachael, Rood Julian I, Uzal Francisco A, McClane Bruce A
Abstract excerpt
Clostridium perfringens type D enterotoxemias have significant economic impact by causing rapid death of several domestic animal species. Consequently, domestic animals are commonly vaccinated, at varying efficacy, with inactivated type D vegetative supernatants. Improved type D vaccines might become possible if the lethal toxins produced by type D isolates were characterized and the contributions of those toxins...
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