In silico mutation of aromatic with aliphatic amino acid residues in Clostridium perfringens epsilon toxin (ETX) reduces its binding efficiency to Caprine Myelin and lymphocyte (MAL) protein receptors.

Abstract excerpt

Enterotoxaemia (ET) is a severe disease that affects domestic ruminants, including sheep and goats, and is caused by Clostridium perfringens type B and D strains. The disease is characterized by the production of Epsilon toxin (ETX), which has a significant impact on the farming industry due to its high lethality. The binding of ETX to the host cell receptor is crucial, but still poorly understood. Therefore, the...

Topics

• Animals
• Amino Acids
• Clostridium perfringens
• Enterotoxemia
• Goats
• Lymphocytes
• Mutation
• Myelin Proteins
• Myelin Sheath
• Myelin and Lymphocyte-Associated Proteolipid Proteins
• Bacterial Toxins