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Article

Class I and IIa histone deacetylases have opposite effects on sclerostin gene regulation.

The Journal of biological chemistry - 5 Sept 2014

Baertschi Stefan, Baur Nina, Lueders-Lefevre Valerie, Voshol Johannes, Keller Hansjoerg

Abstract excerpt

Adult bone mass is controlled by the bone formation repressor sclerostin (SOST). Previously, we have shown that intermittent parathyroid hormone (PTH) bone anabolic therapy involves SOST expression reduction by inhibiting myocyte enhancer factor 2 (MEF2), which activates a distant bone enhancer. Here, we extended our SOST gene regulation studies by analyzing a role of class I and IIa histone deacetylases (HDACs),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 25012661
DOI: 10.1074/jbc.M114.564997
PMCID: PMC4155667

Genes

SOST
HDAC5
PTH
HDAC4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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