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Epigenetic Modifications at the Center of the Barker Hypothesis and Their Transgenerational Implications

2 Dec 2021

Abstract excerpt

Embryo/fetal nutrition and the environment in the reproductive tract influence the subsequent risk of developing adult diseases and disorders, as formulated in the Barker hypothesis. Metabolic syndrome, obesity, heart disease, and hypertension in adulthood have all been linked to unwanted epigenetic programing in embryos and fetuses. Multiple studies support the conclusion that environmental challenges, such as a...

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PMID: 34886453
DOI: 10.3390/ijerph182312728

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