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Article

Adrenergic stress reveals septal hypertrophy and proteasome impairment in heterozygous Mybpc3-targeted knock-in mice.

Journal of muscle research and cell motility - 1 May 2012

Schlossarek Saskia, Schuermann Friederike, Geertz Birgit, Mearini Giulia, Eschenhagen Thomas, Carrier Lucie

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is characterized by asymmetric septal hypertrophy and is often caused by mutations in MYBPC3 gene encoding cardiac myosin-binding protein C. In contrast to humans, who are already affected at the heterozygous state, mouse models develop the phenotype mainly at th...

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Source

Identifiers

PMID: 22076249
DOI: 10.1007/s10974-011-9273-6

Genes

MYBPC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22076249-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adrenergic stress reveals septal hypertrophy and proteasome impairment in heterozygous Mybpc3-targeted knock-in mice.PMID 22076249Read ↗

Contractile dysfunction in a mouse model expressing a heterozygous MYBPC3 mutation associated with hypertrophic cardiomyopathy.Semantic proximity Read ↗

Haploinsufficiency of MYBPC3 exacerbates the development of hypertrophic cardiomyopathy in heterozygous mice.Semantic proximity Read ↗

Characterization of heterozygous and homozygous mouse models with the most common hypertrophic cardiomyopathy mutation MYBPC3c.2373InsG in the Netherlands.Semantic proximity Read ↗

Increased myofilament Ca2+ sensitivity and diastolic dysfunction as early consequences of Mybpc3 mutation in heterozygous knock-in mice.Semantic proximity Read ↗

Diltiazem prevents stress-induced contractile deficits in cardiomyocytes, but does not reverse the cardiomyopathy phenotype in Mybpc3-knock-in mice.Semantic proximity Read ↗

Sexual dimorphic response to exercise in hypertrophic cardiomyopathy-associated MYBPC3-targeted knock-in mice.Semantic proximity Read ↗

Translational investigation of electrophysiology in hypertrophic cardiomyopathySemantic proximity Read ↗

Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathySemantic proximity Read ↗

Transcriptome Analysis of Cardiac Hypertrophic Growth in MYBPC3-Null Mice Suggests Early Responders in Hypertrophic RemodelingSemantic proximity Read ↗

Phosphomimetic cardiac myosin-binding protein C partially rescues a cardiomyopathy phenotype in murine engineered heart tissue.Semantic proximity Read ↗

Lower left ventricular ejection time in<i>MYBPC3</i>variant carriers with overt or subclinical hypertrophic cardiomyopathySemantic proximity Read ↗

Contractile dysfunction irrespective of the mutant protein in human hypertrophic cardiomyopathy with normal systolic function.Semantic proximity Read ↗

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