Article
Pancreatitis severity in mice with impaired CFTR function but pancreatic sufficiency is mediated via ductal and inflammatory cells-Not acinar cells.
Journal of cellular and molecular medicine - 1 May 2021
Trapp Simon, Aghdassi Ali A, Glaubitz Juliane, Sendler Matthias, Weiss Frank Ulrich, Kühn Jens Peter, Kromrey Marie-Luise, Mahajan Ujjwal M, Pallagi Petra, Rakonczay Zoltán, Venglovecz Viktória, Lerch Markus M, Hegyi Peter, Mayerle Julia
Abstract excerpt
Mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR) are an established risk factor for cystic fibrosis (CF) and chronic pancreatitis. Whereas patients with CF usually develop complete exocrine pancreatic insufficiency, pancreatitis patients with CFTR mutations have mostly preserved exocrine pancreatic function. We therefore used a strain of transgenic mice with significant residual...
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