Article
Contribution of calumin to embryogenesis through participation in the endoplasmic reticulum-associated degradation activity.
Developmental biology - 1 Sept 2014
Yamamoto Shinichiro, Yamazaki Tetsuo, Komazaki Shinji, Yamashita Takeshi, Osaki Masako, Matsubayashi Masaya, Kidoya Hiroyasu, Takakura Nobuyuki, Yamazaki Daiju, Kakizawa Sho
Abstract excerpt
Calumin is an endoplasmic reticulum (ER)-transmembrane protein, and little is known about its physiological roles. Here we showed that calumin homozygous mutant embryos die at embryonic days (E) 10.5-11.5. At mid-gestation, calumin was expressed predominantly in the yolk sac. Apoptosis was enhanc...
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