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Article

Quantitative determinants of aerobic glycolysis identify flux through the enzyme GAPDH as a limiting step.

eLife - 9 Jul 2014

Shestov Alexander A, Liu Xiaojing, Ser Zheng, Cluntun Ahmad A, Hung Yin P, Huang Lei, Kim Dongsung, Le Anne, Yellen Gary, Albeck John G, Locasale Jason W

Abstract excerpt

Aerobic glycolysis or the Warburg Effect (WE) is characterized by the increased metabolism of glucose to lactate. It remains unknown what quantitative changes to the activity of metabolism are necessary and sufficient for this phenotype. We developed a computational model of glycolysis and an int...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25009227
DOI: 10.7554/eLife.03342
PMCID: PMC4118620

Genes

GAPDH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25009227-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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