The evaluation of the SMAD1 rs1016792 polymorphism and gene expression on pulmonary hypertension due to congenital heart disease in children: a preliminary study.

doi:10.1080/15257770.2024.2322109

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Article

The evaluation of the SMAD1 rs1016792 polymorphism and gene expression on pulmonary hypertension due to congenital heart disease in children: a preliminary study.

Nucleosides, nucleotides & nucleic acids - 1 Jan 2024

Kimyon Adnan Selim, Çetinkaya Ayşegül, Hallıoğlu Kılınç Olgu, Aras Nurcan

Abstract excerpt

Smad Family Member (SMAD), a protein family responsible for transducing the signal induced by TGF-β into the nucleus, is thought to play a role in the pathology of many heart diseases. Therefore, we aimed to evaluate the influence of the SMAD1 rs1016792 polymorphism and gene expression on pulmonary arterial hypertension (PAH) due to congenital heart disease (CHD) in children. A total of 90 children, 45 of whom...

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PMID: 38410024
DOI: 10.1080/15257770.2024.2322109

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