Article
Characteristics and survival of patients with advanced cancer and p53 mutations.
Oncotarget - 15 Jun 2014
Said Rabih, Ye Yang, Hong David S, Janku Filip, Fu Siqing, Naing Aung, Wheler Jennifer J, Kurzrock Razelle, Thomas Christoforos, Palmer Gary A, Hess Kenneth R, Aldape Kenneth, Tsimberidou Apostolia M
Abstract excerpt
P53 mutations are associated with invasive tumors in mouse models. We assessed the p53mutations and survival in patients with advanced cancer treated in the Phase I Program. Of 691 tested patients, 273 (39.5%) had p53 mutations. Patients with p53 mutations were older (p<.0001) and had higher numbers of liver metastases (p=.005). P53 mutations were associated with higher numbers of other aberrations; PTEN...
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