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Article

Regulation of active DNA demethylation by an α-crystallin domain protein in Arabidopsis.

Molecular cell - 7 Aug 2014

Qian Weiqiang, Miki Daisuke, Lei Mingguang, Zhu Xiaohong, Zhang Huiming, Liu Yunhua, Li Yan, Lang Zhaobo, Wang Jing, Tang Kai, Liu Renyi, Zhu Jian-Kang

Abstract excerpt

DNA methylation patterns are dynamically controlled by DNA methylation and active DNA demethylation, but the mechanisms of regulation of active DNA demethylation are not well understood. Through forward genetic screens for Arabidopsis mutants showing DNA hypermethylation at specific loci and increased silencing of reporter genes, we identified IDM2 (increased DNA methylation 2) as a regulator of DNA demethylation...

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Identifiers

PMID: 25002145
DOI: 10.1016/j.molcel.2014.06.008
PMCID: PMC4302764

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