Article
Gene-body chromatin modification dynamics mediate epigenome differentiation in Arabidopsis.
The EMBO journal - 13 Apr 2017
Inagaki Soichi, Takahashi Mayumi, Hosaka Aoi, Ito Tasuku, Toyoda Atsushi, Fujiyama Asao, Tarutani Yoshiaki, Kakutani Tetsuji
Abstract excerpt
Heterochromatin is marked by methylation of lysine 9 on histone H3 (H3K9me). A puzzling feature of H3K9me is that this modification localizes not only in promoters but also in internal regions (bodies) of silent transcription units. Despite its prevalence, the biological significance of gene-body H3K9me remains enigmatic. Here we show that H3K9me-associated removal of H3K4 monomethylation (H3K4me1) in gene bodies...
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