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Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs.

Bioorganic & medicinal chemistry - 15 Oct 2014

Venkataraman Harini, Verkade-Vreeker Marlies C A, Capoferri Luigi, Geerke Daan P, Vermeulen Nico P E, Commandeur Jan N M

Abstract excerpt

Cytochrome P450 BM3 mutants are promising biocatalysts for the production of drug metabolites. In the present study, the ability of cytochrome P450 BM3 mutants to produce oxidative metabolites of structurally related NSAIDs meclofenamic acid, mefenamic acid and tolfenamic acid was investigated. A library of engineered P450 BM3 mutants was screened with meclofenamic acid (1) to identify catalytically active and...

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PMID: 24999003
DOI: 10.1016/j.bmc.2014.06.022

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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