Article
Drug metabolite generation using a laboratory evolved NADPH independent cytochrome P450: application of in vitro and in silico approaches.
Drug metabolism letters - 1 Mar 2013
Chigorimbo-Murefu Nyaradzo T L, Njoroge Mathew, Louw Stefan, Mugumbate Grace, Chibale Kelly
Abstract excerpt
Twelve disparate drugs were subjected to metabolite generation by a laboratory evolved bacterial cytochrome P450 to investigate feasibility of the bacterial CYP to generate drug metabolites. Seven drugs were metabolised by the bacterial cytochromes to give diverse metabolites, which were compared to human metabolites reported in literature. Several non human metabolites were also generated by the bacterial CYP in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.