Article

Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolines

2013-01-01

Abstract excerpt

The synthesis and antiproliferative activity of eleven 3-(pyrid-2-yl)-pyrazolines in two cancer cell lines are reported. X-ray crystallography was obtained of the lead compound 8i which was screened in the NCI 60 human tumour cell line and displayed sub-micromolar activity. Cell cycle analysis, in vitro tubulin assay and confocal microscopy are also reported and suggest that the lead compound disrupts microtubule...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 52de526b-6c92-5ca6-9f1b-179022283abe
DOI: 10.1039/c3md00077j

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 9 closest

Synthesis and antiproliferative activity of some 3-(pyrid-2-yl)-pyrazolinesDOI 10.1039/c3md00077jRead

Design, synthesis and biological evaluation of imidazopyridine–propenone conjugates as potent tubulin inhibitorsSemantic proximity Read

Design and synthesis of 2-amino-pyrazolopyridines as Polo-like kinase 1 inhibitors.Semantic proximity Read

Exploiting the antiproliferative potential of spiropyrazoline oxindoles in a human ovarian cancer cell lineSemantic proximity Read

Discovery of novel pyrazolo[3,4-b]pyridine scaffold-based derivatives as potential PIM-1 kinase inhibitors in breast cancer MCF-7 cellsSemantic proximity Read

Exploration Of 4( <i>1H</i> )-Pyridones As A Novel Family Of Potent Antimalarial Inhibitors Of The Plasmodial Cytochrome bc1Semantic proximity Read

Antimitotic Sulfonamides Inhibit Microtubule Assembly Dynamics and Cancer Cell ProliferationSemantic proximity Read

New lithocholic and chenodeoxycholic piperazinylcarboxamides with antiproliferative and pro-apoptotic effects on human cancer cell linesSemantic proximity Read

A novel chalcone derivative which acts as a microtubule depolymerising agent and an inhibitor of P-gp and BCRP in in-vitro and in-vivoglioblastoma modelsSemantic proximity Read

Comparative in vivo evaluation of polyalkoxy substituted 4H-chromenes and oxa-podophyllotoxins as microtubule destabilizing agents in the phenotypic sea urchin embryo assay.Semantic proximity Read