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Initiation of hepatic stellate cell activation extends into chronic liver disease

27 Nov 2021

Abstract excerpt

Activated hepatic stellate cells (aHSC) are the main source of extra cellular matrix in liver fibrosis. Activation is classically divided in two phases: initiation and perpetuation. Currently, HSC-based therapeutic candidates largely focus on targeting the aHSCs in the perpetuation phase. However, the importance of HSC initiation during chronic liver disease (CLD) remains unclear. Here, we identified...

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PMID: 34839349
DOI: 10.1038/s41419-021-04377-1

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