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Article

Cleavage of the Drosophila screw prodomain is critical for a dynamic BMP morphogen gradient in embryogenesis.

Developmental biology - 15 May 2014

Künnapuu Jaana, Tauscher Petra M, Tiusanen Nina, Nguyen Minh, Löytynoja Ari, Arora Kavita, Shimmi Osamu

Abstract excerpt

Dorsoventral patterning of the Drosophila embryo is regulated by graded distribution of bone morphogenetic proteins (BMPs) composed of two ligands, decapentaplegic (Dpp) a BMP2/4 ortholog and screw (Scw) a BMP5/6/7/8 family member. scw(E1) encodes an unusual allele that was isolated as a dominant enhancer of partial loss-of-function mutations in dpp. However, the molecular mechanisms that underlie this genetic...

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Source

Identifiers

PMID: 24560644
DOI: 10.1016/j.ydbio.2014.02.007

Genes

BMP2
BMP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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