Article
Chromatin-associated periodicity in genetic variation downstream of transcriptional start sites.
Science (New York, N.Y.) - 16 Jan 2009
Sasaki Shin, Mello Cecilia C, Shimada Atsuko, Nakatani Yoichiro, Hashimoto Shin-Ichi, Ogawa Masako, Matsushima Kouji, Gu Sam Guoping, Kasahara Masahiro, Ahsan Budrul, Sasaki Atsushi, Saito Taro, Suzuki Yutaka, Sugano Sumio, Kohara Yuji, Takeda Hiroyuki, Fire Andrew, Morishita Shinichi
Abstract excerpt
Might DNA sequence variation reflect germline genetic activity and underlying chromatin structure? We investigated this question using medaka (Japanese killifish, Oryzias latipes), by comparing the genomic sequences of two strains (Hd-rR and HNI) and by mapping approximately 37.3 million nucleosome cores from Hd-rR blastulae and 11,654 representative transcription start sites from six embryonic stages. We...
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