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Article

Impact of chromatin structure on sequence variability in the human genome.

Nature structural & molecular biology - 1 Apr 2011

Tolstorukov Michael Y, Volfovsky Natalia, Stephens Robert M, Park Peter J

Abstract excerpt

DNA sequence variations in individual genomes give rise to different phenotypes within the same species. One mechanism in this process is the alteration of chromatin structure due to sequence variation that influences gene regulation. We composed a high-confidence collection of human single-nucleotide polymorphisms and indels based on analysis of publicly available sequencing data and investigated whether the DNA...

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PMID: 21399641
DOI: 10.1038/nsmb.2012
PMCID: PMC3188321

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