Article
The proton pump inhibitor lansoprazole, but not rabeprazole, the increased blood concentrations of calcineurin inhibitors in Japanese patients with connective tissue diseases.
Internal medicine (Tokyo, Japan) - 1 Jan 2014
Isoda Kentaro, Takeuchi Tohru, Kotani Takuya, Hirano-Kuwata Suzue, Shoda Takeshi, Hata Kenichiro, Yoshida Shuzo, Makino Shigeki, Hanafusa Toshiaki
Abstract excerpt
OBJECTIVE: Proton pump inhibitors (PPIs) are frequently coadministered with calcineurin inhibitors (CNIs) such as tacrolimus (TAC) and cyclosporin A (CSA), to treat or prevent upper gastrointestinal complications in Japanese patients with connective tissue diseases (CTDs). The coadministration of PPIs increases the blood concentration of TAC due to drug interaction. We retrospectively investigated the influence...
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