Article
Influence of Proton Pump Inhibitors on Mycophenolic Acid Pharmacokinetics in Patients With Renal Transplantation and the Relationship With Cytochrome 2C19 Gene Polymorphism.
Transplantation proceedings - 1 Apr 2017
Ciftci H S, Karadeniz M S, Tefik T, Caliskan Y, Yazıcı H, Demir E, Turkmen A, Nane I, Oguz F S, Aydin F
Abstract excerpt
BACKGROUND: Most patients have serious digestive complications after renal transplantation. Therefore, it is important to protect gastrointestinal function to improve the survival rate of transplant patients. Proton pump inhibitors (PPIs) such as lansoprazole and rabeprazole are widely administered to renal transplant patients with mycophenolic acid (MPA) in the perioperative period. PPIs are metabolized by...
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