Article
Hepatic drug interaction between tacrolimus and lansoprazole in a bone marrow transplant patient receiving voriconazole and harboring CYP2C19 and CYP3A5 heterozygous mutations.
Clinical therapeutics - 1 Aug 2011
Iwamoto Takuya, Monma Fumihiko, Fujieda Atsushi, Nakatani Kaname, Katayama Naoyuki, Okuda Masahiro
Abstract excerpt
BACKGROUND: A drug interaction between oral tacrolimus (TAC) and lansoprazole (LAN) has been reported in patients with CYP2C19 hetero/homozygous mutations and the CYP3A5 *3/*3 genotype. A PubMed search (implemented March 16, 2011) using search terms drug interaction, tacrolimus, and lansoprazole failed to identify drug interactions in CYP3A5 extensive metabolizers and parenterally administered TAC. OBJECTIVE: The...
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