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Article

Effect of lansoprazole and rabeprazole on tacrolimus pharmacokinetics in healthy volunteers with CYP2C19 mutations.

The Journal of pharmacy and pharmacology - 1 Aug 2004

Itagaki Fumio, Homma Masato, Yuzawa Kenji, Nishimura Masuhiro, Naito Shinsaku, Ueda Nobuhiko, Ohkohchi Nobuhiro, Kohda Yukinao

Abstract excerpt

The aim of this study was to investigate the effects of the proton pump inhibitors (PPIs), lansoprazole and rabeprazole, on tacrolimus pharmacokinetics in healthy volunteers with mutations in the cytochrome P450 (CYP) 2C19 gene (CYP2C19). An open-label crossover study was performed with 19 healthy subjects. Tacrolimus (2 mg) was administered orally with and without lansoprazole (30 mg per day for 4 days) or...

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Identifiers

PMID: 15285851
DOI: 10.1211/0022357043914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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