Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

One-year follow-up of transgene expression by integrase-defective lentiviral vectors and their therapeutic potential in spinocerebellar ataxia model mice.

Gene therapy - 1 Sept 2014

Saida H, Matsuzaki Y, Takayama K, Iizuka A, Konno A, Yanagi S, Hirai H

Abstract excerpt

We examined integrase-defective lentiviral vectors (IDLVs) with a mutant (D64V) integrase in terms of their residual integration capability, the levels and duration of transgene expression and their therapeutic potential in comparison to wild-type lentiviral vectors (WTLVs) with a wild-type integrase gene. Compared with WTLVs, the IDLV-mediated proviral integration into host-cell chromosomes was approximately...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cerebellum
Share to Genetic Vectors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to GTP Phosphohydrolases

Share to Integrases

Share to Lentivirus

Share to Rotarod Performance Test

Share to Spinocerebellar Ataxias

Share to Transgenes

Source

Identifiers

PMID: 24989813
DOI: 10.1038/gt.2014.60

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

One-year follow-up of transgene expression by integrase-defective lentiviral vectors and their therapeutic potential in spinocerebellar ataxia model mice.PMID 24989813Read ↗

A Large U3 Deletion Causes Increased In Vivo Expression From a Nonintegrating Lentiviral VectorSemantic proximity Read ↗

Non-integrating lentiviral vectors.Semantic proximity Read ↗

Integration-deficient lentiviral vectors: a slow coming of age.Semantic proximity Read ↗

Development of a Self-Inactivating Lentivirus VectorSemantic proximity Read ↗

Characterization of Lentiviral Vector-Mediated Gene Transfer in Adult Mouse BrainSemantic proximity Read ↗

Overexpression of mutant ataxin-3 in mouse cerebellum induces ataxia and cerebellar neuropathology.Semantic proximity Read ↗

Cerebellar Allografts Survive and Transiently Alleviate Ataxia in a Transgenic Model of Spinocerebellar Ataxia Type-1Semantic proximity Read ↗

Reversal of Pathology in the Entire Brain of Mucopolysaccharidosis Type VII Mice after Lentivirus-Mediated Gene TransferSemantic proximity Read ↗

Histone deacetylase inhibition activates transgene expression from integration-defective lentiviral vectors in dividing and non-dividing cells.Semantic proximity Read ↗

Silencing mutant ataxin-3 rescues motor deficits and neuropathology in Machado-Joseph disease transgenic mice.Semantic proximity Read ↗

Adeno-associated viral vector-mediated ApoE expression in Alzheimer's disease mice: low CNS immune response, long-term expression, and astrocyte specificity.Semantic proximity Read ↗

In vivo transduction of murine cerebellar Purkinje cells by HIV-derived lentiviral vectorsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.