Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adeno-associated viral vector-mediated ApoE expression in Alzheimer's disease mice: low CNS immune response, long-term expression, and astrocyte specificity.

Frontiers in bioscience : a journal and virtual library - 1 May 2004

Feng Xuan, Eide Fernette F, Jiang Hong, Reder Anthony T

Abstract excerpt

Recombinant Adenovirus and Adeno-associated virus (AAV) are highly effective vehicles for gene transfer into CNS cells. However, the duration of gene expression and the cytotoxicity to cells are quite different between these viral approaches. We initially investigated these distinctions by stereo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apolipoproteins E
Share to Astrocytes
Share to Central Nervous System

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dependovirus

Share to Genetic Vectors

Share to Glial Fibrillary Acidic Protein

Share to Hippocampus

Share to Recombinant Fusion Proteins

Source

Identifiers

PMID: 14977565
DOI: 10.2741/1323

Genes

GFAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-14977565-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adeno-associated viral vector-mediated ApoE expression in Alzheimer's disease mice: low CNS immune response, long-term expression, and astrocyte specificity.PMID 14977565Read ↗

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement miceSemantic proximity Read ↗

Profile and Regulation of Apolipoprotein E (ApoE) Expression in the CNS in Mice with Targeting of Green Fluorescent Protein Gene to the ApoE LocusSemantic proximity Read ↗

Adeno-Associated Viral Vectors Serotype 8 for Cell-Specific Delivery of Therapeutic Genes in the Central Nervous SystemSemantic proximity Read ↗

Aging reduces glial uptake and promotes extracellular accumulation of Aβ from a lentiviral vectorSemantic proximity Read ↗

One-year Expression From High-capacity Adenoviral Vectors in the Brains of Animals With Pre-existing Anti-adenoviral Immunity: Clinical ImplicationsSemantic proximity Read ↗

AAVrh.10-Mediated APOE2 Central Nervous System Gene Therapy for APOE4-Associated Alzheimer's DiseaseSemantic proximity Read ↗

Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models.Semantic proximity Read ↗

Expression of amyloid-β antibody via AAV of CNS tropism alleviates Alzheimer’s disease in miceSemantic proximity Read ↗

Adenovirus in the brain: recent advances of gene therapy for neurodegenerative diseasesSemantic proximity Read ↗

Human apolipoprotein E allele-specific brain expressing transgenic mice.Semantic proximity Read ↗

Astrocytic expression of the Alzheimer's disease risk allele, ApoEε4, potentiates neuronal tau pathology in multiple preclinical models.Semantic proximity Read ↗

Engineered HSV vector achieves safe long-term transgene expression in the central nervous systemSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.