Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A population-based study of KCNH7 p.Arg394His and bipolar spectrum disorder

30 Jun 2014

Abstract excerpt

We conducted blinded psychiatric assessments of 26 Amish subjects (52 ± 11 years) from four families with prevalent bipolar spectrum disorder, identified 10 potentially pathogenic alleles by exome sequencing, tested association of these alleles with clinical diagnoses in the larger Amish Study of Major Affective Disorder (ASMAD) cohort, and studied mutant potassium channels in neurons. Fourteen of 26 Amish had...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bipolar Disorder and Treatment
Share to Cardiac electrophysiology and arrhythmias
Share to Ion channel regulation and function

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24986916
DOI: 10.1093/hmg/ddu335

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A population-based study of KCNH7 p.Arg394His and bipolar spectrum disorderPMID 24986916Read ↗

Association of rare missense variants in the second intracellular loop of NaV1.7 sodium channels with familial autism.Semantic proximity Read ↗

Molecular and functional characterization of common polymorphisms in HERG (KCNH2) potassium channels.Semantic proximity Read ↗

<i>KCNH1</i> variants associated with neurodevelopmental disorders exhibit prominent gain-of-functionSemantic proximity Read ↗

Identification and In-Silico study of non-synonymous functional SNPs in the human SCN9A gene.Semantic proximity Read ↗

Two four-marker haplotypes on 7q36.1 region indicate that the potassium channel gene HERG1 (KCNH2, Kv11.1) is related to schizophrenia: a case control study.Semantic proximity Read ↗

Exome analysis in 34 sudden unexplained death (SUD) victims mainly identified variants in channelopathy-associated genesSemantic proximity Read ↗

Carriers of<i>SCN9A</i>variants linked to inherited and acquired pain syndromes show no alteration in the prevalence of pain or analgesic usage in the UK Biobank cohortSemantic proximity Read ↗

KCNQ1 and Long QT Syndrome in 1/45 Amish: The Road From Identification to Implementation of Culturally Appropriate Precision Medicine.Semantic proximity Read ↗

A common polymorphism in KCNH2 (HERG) hastens cardiac repolarization.Semantic proximity Read ↗

Role of sequence variations in the human ether-a-go-go-related gene (HERG, KCNH2) in the Brugada syndrome.Semantic proximity Read ↗

Phenome-wide association study of P2RX7 identifies schizophrenia and mood disorders as primary associated phenotypes.Semantic proximity Read ↗

Potassium Voltage-Gated Channel Subfamily H Member 1 (KCNH1) Missense Mutation Causing Epileptic Encephalopathy And Autistic Behaviour.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.