Article
Role of sequence variations in the human ether-a-go-go-related gene (HERG, KCNH2) in the Brugada syndrome.
Cardiovascular research - 1 Dec 2005
Verkerk Arie O, Wilders Ronald, Schulze-Bahr Eric, Beekman Leander, Bhuiyan Zahurul A, Bertrand Jessica, Eckardt Lars, Lin Dongxin, Borggrefe Martin, Breithardt Günter, Mannens Marcel M A M, Tan Hanno L, Wilde Arthur A M, Bezzina Connie R
Abstract excerpt
BACKGROUND: Brugada syndrome (BrS) is an inherited electrical disorder associated with a high incidence of sudden death. In a minority of patients, it has been linked to mutations in SCN5A, the gene encoding the pore-forming alpha-subunit of the cardiac Na(+) channel. Other causally related genes still await identification. We evaluated the role of HERG (KCNH2), which encodes the alpha-subunit of the rapid...
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