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Article

In vivo individual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9.

Biopharmaceutics & drug disposition - 1 Sept 2016

Iwasaki Kazuhide, Kitsugi Yusuke, Ikeda Kanami, Yoshikawa Takahiro, Hosaka Shinya, Uehara Shotaro, Uno Yasuhiro, Utoh Masahiro, Yamazaki Hiroshi

Abstract excerpt

Cynomolgus monkeys are used frequently in preclinical studies for new drug development due to their evolutionary closeness to humans. An antiretroviral drug, efavirenz, is a typical probe substrate for human cytochrome P450 (P450) 2B6, but is mainly metabolized by cynomolgus monkey P450 2C9. In this study, plasma concentrations of efavirenz were assessed in six cynomolgus monkeys genotyped for P450 2C9...

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Identifiers

PMID: 27417918
DOI: 10.1002/bdd.2021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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