Article
A null allele impairs function of CYP2C76 gene in cynomolgus monkeys: a possible genetic tool for generation of a better animal model in drug metabolism.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2009
Uno Yasuhiro, Sakuraba Hiroko, Uehara Shotaro, Kumano Takayuki, Matsuno Kiyomi, Nakamura Chika, Kito Go, Kamataki Tetsuya, Nagata Ryoichi
Abstract excerpt
The monkey CYP2C76 gene does not correspond to any of the human CYP2C genes, and its enzyme is at least partly responsible for the species difference occasionally seen in drug metabolism between monkeys and humans. To establish a line and/or lines of monkeys that are expected to show metabolic patterns highly similar to humans, we set out to find monkeys that lacked CYP2C76 activity. By genetic screening of 73...
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