Article
The Role of Hypoxia Inducible Factor-1 Alpha in Bypassing Oncogene-Induced Senescence
1 Jul 2014
Abstract excerpt
Oncogene induced senescence (OIS) is a sustained anti-proliferative response acutely induced in primary cells via activation of mitogenic oncogenes such as Ras/BRAF. This mechanism acts as an initial barrier preventing normal cells transformation into malignant cell. Besides oncogenic activation and DNA damage response (DDR), senescence is modulated by a plethora of other factors, and one of the most important...
Topics
Join the communities discussing this publication.