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Article

Effects of PRE and POST therapy drug-pressure selected mutations on HIV-1 protease conformational sampling.

FEBS letters - 25 Aug 2014

Carter Jeffrey D, Gonzales Estrella G, Huang Xi, Smith Adam N, de Vera Ian Mitchelle S, D'Amore Peter W, Rocca James R, Goodenow Maureen M, Dunn Ben M, Fanucci Gail E

Abstract excerpt

Conformational sampling of pre- and post-therapy subtype B HIV-1 protease sequences derived from a pediatric subject infected via maternal transmission with HIV-1 were characterized by double electron-electron resonance spectroscopy. The conformational ensemble of the PRE construct resembles native-like inhibitor bound states. In contrast, the POST construct, which contains accumulated drug-pressure selected...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24983495
DOI: 10.1016/j.febslet.2014.06.051
PMCID: PMC4335667

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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