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Article

Unveiling the Impact of Drug-Sensitive Mutations on HIV-1 Protease Dynamics: A Molecular Dynamics Simulation Study of the T12A, L63Q, and H69N Variants.

International journal of molecular sciences - 25 Apr 2026

Srihi Haythem, Abid Nabil, Fabeni Lavinia, Precone Caterina, Déméné Hélène, Chillemi Giovanni

Abstract excerpt

HIV-1 protease (PR) is an essential enzyme in the viral life cycle and a primary target of antiretroviral therapies, particularly protease inhibitors (PIs). Understanding the dynamics of viral evolution and the factors governing the emergence or loss of resistance-associated mutations is critical for improving PI efficacy and managing drug resistance in HIV/AIDS treatment. In this study, we investigated the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42123414
DOI: 10.3390/ijms27093832
PMCID: PMC13164047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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