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Article

The role of select subtype polymorphisms on HIV-1 protease conformational sampling and dynamics.

The Journal of biological chemistry - 13 Jun 2014

Huang Xi, Britto Manuel D, Kear-Scott Jamie L, Boone Christopher D, Rocca James R, Simmerling Carlos, Mckenna Robert, Bieri Michael, Gooley Paul R, Dunn Ben M, Fanucci Gail E

Abstract excerpt

HIV-1 protease is an essential enzyme for viral particle maturation and is a target in the fight against HIV-1 infection worldwide. Several natural polymorphisms are also associated with drug resistance. Here, we utilized both pulsed electron double resonance, also called double electron-electron resonance, and NMR (15)N relaxation measurements to characterize equilibrium conformational sampling and backbone...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24742668
DOI: 10.1074/jbc.M114.571836
PMCID: PMC4059161

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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