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Article

Dynamics of T-cell IFN-γ and miR-29a expression during active pulmonary tuberculosis

30 Jun 2014

Abstract excerpt

IFN-γ is crucial for protection against Mycobacterium tuberculosis. miR-29 was recently shown to non-redundantly inhibit IFN-γ. Here, we investigated IFN-γ and miR-29a expression dynamics of CD4(+) T cells from patients during active tuberculosis (TB) (n = 32) and in household contacts who were latently M. tuberculosis infected (n = 19) from Ghana. Whereas M. tuberculosis-specific IFN-γ expression was similar...

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PMID: 24981709
DOI: 10.1093/intimm/dxu068

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