Article
Concordance between IFNγ gene +874 A/T polymorphism and interferon-γ expression in a TB-endemic indigenous setting.
Revista da Sociedade Brasileira de Medicina Tropical - 1 Jan 2000
Araujo Zaida, Palacios Andrea, Biomon Rubén, Rivas-Santiago Bruno, Serrano Carmen Judith, Enciso-Moreno Leonor, López-Ramos Juan Ernesto, Wide Albina, Jiménez Juan Carlos, Larrea Carlos Fernández de, Enciso-Moreno José Antonio
Abstract excerpt
INTRODUCTION:: Interferon-γ (IFN-γ) plays a crucial role in resistance to mycobacterial diseases; accordingly, variants of the gene encoding this cytokine may be associated with elevated risk of contracting pulmonary tuberculosis (TB). METHODS:: Blood samples were collected from 135 Warao indigenous individuals with newly diagnosed sputum culture-positive TB. Of these, 24 were diagnosed with active tuberculosis...
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