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Article

Serum supplemented culture medium masks hypertrophic phenotypes in human pluripotent stem cell derived cardiomyocytes.

Journal of cellular and molecular medicine - 1 Aug 2014

Dambrot Cheryl, Braam Stefan R, Tertoolen Leon G J, Birket Matthew, Atsma Douwe E, Mummery Christine L

Abstract excerpt

It has been known for over 20 years that foetal calf serum can induce hypertrophy in cultured cardiomyocytes but this is rarely considered when examining cardiomyocytes derived from pluripotent stem cells (PSC). Here, we determined how serum affected cardiomyocytes from human embryonic- (hESC) and induced pluripotent stem cells (hiPSC) and hiPSC from patients with hypertrophic cardiomyopathy linked to a mutation...

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Source

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Identifiers

PMID: 24981391
DOI: 10.1111/jcmm.12356
PMCID: PMC4190898

Genes

MYBPC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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