Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Computational prediction of a putative binding site on drp1: implications for antiparkinsonian therapy.

Journal of chemical information and modeling - 28 Jul 2014

Pradeep Hanumanthappa, Rajanikant G Krishnamurthy

Abstract excerpt

Parkinson's disease is the second most common neurodegenerative disorder, for which no cure or disease-modifying therapies exist. It is evident that mechanisms impairing mitochondrial dynamics will damage cell signaling pathways, leading to neuronal death that manifests as Parkinson's disease. Dy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allosteric Regulation
Share to Antiparkinson Agents
Share to Drug Design

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dynamins

Share to GTP Phosphohydrolases

Share to Microtubule-Associated Proteins

Share to Molecular Docking Simulation

Share to Neuroprotective Agents

Source

Identifiers

PMID: 24977305
DOI: 10.1021/ci500243h

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24977305-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Computational prediction of a putative binding site on drp1: implications for antiparkinsonian therapy.PMID 24977305Read ↗

Dynamin-related protein 1: A protein critical for mitochondrial fission, mitophagy, and neuronal death in Parkinson’s diseaseSemantic proximity Read ↗

Mitochondrial dynamics and its impact on human health and diseases: inside the DRP1 blackbox.Semantic proximity Read ↗

Characterization of pathogenic missense mutations in nuclear encoded mitochondrial dynamin -1 like protein.Semantic proximity Read ↗

Dynamics of Dynamin-Related Protein 1 in Alzheimer’s Disease and Other Neurodegenerative DiseasesSemantic proximity Read ↗

Identification of Kinase inhibitors as PINK1 activators for the treatment of Parkinson’s DiseaseSemantic proximity Read ↗

Mimicking human Drp1 disease-causing mutations in yeast Dnm1 reveals altered mitochondrial dynamics.Semantic proximity Read ↗

Rational drug design targeting intrinsically disordered proteinsSemantic proximity Read ↗

Functional identification of two variants in unrelated Chinese patients with DNM1L-related mitochondrial disorders.Semantic proximity Read ↗

Targeting Dual-Impact FBXO7 Mutants Implicated in Parkinson’s Disease and Cancer: An Integrated Approach Using Density Functional Theory, Molecular Docking, and Molecular DynamicsSemantic proximity Read ↗

Alteration of Drp1 Expression in Drosophila Models of Parkinson DiseaseSemantic proximity Read ↗

Serine 39 in the GTP-binding domain of Drp1 is involved in shaping mitochondrial morphology.Semantic proximity Read ↗

A profound computational study to prioritize the disease-causing mutations in PRPS1 gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.